U.S. President Donald Trump said he wanted a "real end" to the nuclear problem with Iran and indicated he may send senior American officials to meet with the Islamic Republic as the Israel-Iran air war raged for a fifth straight day.

He made the comments during his midnight departure from Canada, where he attended the Group of Seven nations summit on Monday, according to comments posted by a CBS News reporter on social media platform X.

Trump predicted that Israel would not be easing its attacks on Iran. "You're going to find out over the next two days. You're going to find out. Nobody's slowed up so far," the CBS journalist quoted Trump as saying on Air Force One.

He said "I may", on the prospect of sending U.S. Middle East Envoy Steve Witkoff or Vice President JD Vance to meet with Iran.

Washington has said Trump was still aiming for a nuclear deal with Iran, even as the military confrontation unfolds.

World leaders meeting at the Group of Seven summit called for a de-escalation of the worst-ever conflict between the regional foes, saying Iran was a source of instability and must never have a nuclear weapon while affirming Israel's right to defend itself.

Trump, who left the summit early due to the Middle East situation, said his departure had "nothing to do with" working on a deal between Israel and Iran after French President Emmanuel Macron said the U.S. had initiated a ceasefire proposal.

"Wrong! He has no idea why I am now on my way to Washington, but it certainly has nothing to do with a Cease Fire. Much bigger than that," Trump wrote on his Truth Social platform late on Monday.

Israel launched its air war with a surprise attack that has killed nearly the entire top echelon of Iran's military commanders and its leading nuclear scientists. It says it now has control of Iranian airspace and intends to escalate the campaign in the coming days.

Trump has consistently said the Israeli assault could end quickly if Iran agreed to U.S. demands that it accept strict curbs on its nuclear programme.

"Simply stated, IRAN CAN NOT HAVE A NUCLEAR WEAPON. I said it over and over again! Everyone should immediately evacuate Tehran!" Trump said on Monday.

Iran's Revolutionary Guards said on Tuesday that a "more powerful" new wave of missiles was recently launched towards Israel, the state news agency reported. A senior Iranian army commander said a new wave of drones would hit Israel.

Three people were killed and four injured in Iran's central city of Kashan in an Israeli attack, Iran's Nournews reported on Tuesday.

EXPLOSIONS, AIR DEFENCE FIRE

Iranian media also reported explosions and heavy air defence fire in Tehran early on Tuesday, with smoke rising in the city's east after an explosion of suspected Israeli projectiles. Air defences were activated also in Natanz, home to key nuclear installations 320 km (200 miles) away, the Asriran news website reported.

Doctors and nurses have been recalled from leave to carry out their duties, Iranian media reported.

Khorramabad city MP Reza Sepahvand told the Iranian labour news agency that most incidents happening in Iran are due to "infiltrators" rather than direct action from Israel, adding that 21 people were killed in the western province of Lorestan.

World oil markets are on high alert for any developments in the conflict that could hit global supply.

A shipping incident near the Strait of Hormuz, off the coast of the United Arab Emirates early on Tuesday morning was not security related but a result of ships colliding. The UAE coast guard said it had evacuated 24 people from oil tanker ADALYNN following a collision between two ships in the Gulf of Oman, near Hormuz. About a fifth of the world's total oil consumption passes through the waterway.

Naval sources have told Reuters that electronic interference with commercial ship navigation systems has surged in recent days around the Strait of Hormuz and the wider Gulf, which is having an impact on vessels sailing through the region.

Israel's military said on Tuesday that it killed Iran's wartime chief of staff. Israel also said it carried out extensive strikes on Iranian military targets including weapons storage sites and missile launchers.

Iranian officials have reported 224 deaths, mostly civilians, while Israel said 24 civilians had been killed. Israeli Finance Minister Bezalel Smotrich said nearly 3,000 Israelis had been evacuated due to damage from Iranian strikes.

Sources told Reuters that Tehran had asked Oman, Qatar and Saudi Arabia to urge Trump to pressure Israeli Prime Minister Benjamin Netanyahu to agree to an immediate ceasefire. In return, Iran would show flexibility in nuclear negotiations, according to two Iranian and three regional sources.

CHINESE URGED TO LEAVE ISRAEL

"If President Trump is genuine about diplomacy and interested in stopping this war, next steps are consequential," Iranian Foreign Minister Abbas Araqchi said on X. "Israel must halt its aggression, and absent a total cessation of military aggression against us, our responses will continue."

Iran denies seeking nuclear weapons and has pointed to its right to nuclear technology for peaceful purposes, including enrichment, as a party to the Nuclear Non-Proliferation Treaty.

Israel, which is not a party to the NPT, is the only country in the Middle East widely believed to have nuclear weapons. Israel does not deny or confirm that.

With security concerns growing and Israeli airspace closed because of the war, the Chinese embassy in Israel urged its citizens to leave the country via land border crossings as soon as possible.

The conflict escalated on Monday with Israel attacking Iran's uranium enrichment facilities.

Rafael Grossi, head of the International Atomic Energy Agency, told the BBC that the Natanz plant sustained extensive damage, likely destroying 15,000 centrifuges, while Iran's Fordow plant remained largely intact.

Reuters

Updated 5.24pm

Trump says he wants 'real end' to end nuclear problem with Iran