The Hang Seng Index closed 1.45 percent or 401.86 points lower at 27,321.98 points.
The mainboard turnover was about HK$139.6 billion.
Among blue-chips, CSPC Pharma (1093) gained by 1.89 percent, the best performer. Haidilao International (6862) tumbled by 5.45 percent, the biggest loser.
The Hang Seng Tech Index slumped by 2.96 percent, at 7,268.14 points.
The SSE Composite Index dropped by 0.68 percent, at 3,550.40 points. The Shenzhen Composite Index shed 1.43 percent at 2,468.14 points.